| RUN_NAME | DecodeME_brain_tsv |
|---|---|
| K_VALUES | 5 7 15 |
| STAT_METHOD | median |
| Z_FLAG | --z-score |
| SORT_FLAG | None |
| FDR Cutoff | 0.05 |
|---|---|
| Enrichr Combined Score Min | 10 |
| Max Terms per Category | 5 |
| Max Tissues Shown | 5 |
| Max Genes Shown | 20 |
This cluster contains 17 genes.
Average Silhouette Score: 0.129.
Highest expression is observed in: amygdala__oligodendrocyte, hypothalamus__oligodendrocyte, hypothalamus__leukocyte, amygdala__central nervous system macrophage, hypothalamus__central nervous system macrophage.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- SMART: Domain in SPla and the RYanodine Receptor. (SM00449) (FDR: 0.010); Associated with SPRY domains (SM00589) (FDR: 0.010) *(Total significant: 2)*
- PMID: (1997) A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID:9149941) (FDR: 0.007) *(Total significant: 1)*
- HPO: Wellbeing measurement (EFO:0007869) (FDR: 4.61e-08); Depressive symptom measurement (EFO:0007006) (FDR: 0.008) *(Total significant: 2)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- Reactome_2022: Butyrophilin (BTN) Family Interactions R-HSA-8851680 (Adj. P: 0.001, Combined Score: 2667.47); RAC2 GTPase Cycle R-HSA-9013404 (Adj. P: 0.023, Combined Score: 187.79); RAC3 GTPase Cycle R-HSA-9013423 (Adj. P: 0.023, Combined Score: 171.53); Adaptive Immune System R-HSA-1280218 (Adj. P: 0.023, Combined Score: 47.46) *(Total significant: 4)*
- OMIM_Disease: alzheimer disease (Adj. P: 0.044, Combined Score: 190.71) *(Total significant: 1)*
Top Genes (by silhouette):
This cluster contains 7 genes.
Average Silhouette Score: 0.046.
Highest expression is observed in: hypothalamus__endothelial cell, basal_ganglia__endothelial cell, cerebellum__endothelial cell, midbrain__endothelial cell, amygdala__endothelial cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- PMID: (2010) Identification of two novel chromosome regions associated with isolated growth hormone deficiency. (PMID:21284329) (FDR: 0.017) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of Peroxisome Proliferator Activated Receptor Signaling Pathway (GO:0035360) (Adj. P: 0.024, Combined Score: 5287.72); tRNA Aminoacylation for Mitochondrial Protein Translation (GO:0070127) (Adj. P: 0.024, Combined Score: 3338.15); Negative Regulation of Nitric Oxide Biosynthetic Process (GO:0045019) (Adj. P: 0.024, Combined Score: 2797.66); Negative Regulation of Nitric Oxide Metabolic Process (GO:1904406) (Adj. P: 0.024, Combined Score: 2797.66); NAD Biosynthesis via Nicotinamide Riboside Salvage Pathway (GO:0034356) (Adj. P: 0.024, Combined Score: 2398.85) ... *(Total significant: 55. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Galactosyltransferase Activity (GO:0008378) (Adj. P: 0.020, Combined Score: 2093.27); GABA Receptor Binding (GO:0050811) (Adj. P: 0.020, Combined Score: 2093.27); Intramolecular Oxidoreductase Activity, Transposing C=C Bonds (GO:0016863) (Adj. P: 0.020, Combined Score: 1497.03); UDP-galactosyltransferase Activity (GO:0035250) (Adj. P: 0.021, Combined Score: 818.24); Protein Kinase A Regulatory Subunit Binding (GO:0034237) (Adj. P: 0.021, Combined Score: 730.06) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Reactome_2022: Beta-oxidation Of Very Long Chain Fatty Acids R-HSA-390247 (Adj. P: 0.029, Combined Score: 1852.16); Eicosanoids R-HSA-211979 (Adj. P: 0.029, Combined Score: 1657.40); Synthesis Of Bile Acids And Bile Salts Via 24-Hydroxycholesterol R-HSA-193775 (Adj. P: 0.029, Combined Score: 1362.86); N-Glycan Antennae Elongation R-HSA-975577 (Adj. P: 0.029, Combined Score: 1249.08); Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) R-HSA-2162123 (Adj. P: 0.029, Combined Score: 1249.08) ... *(Total significant: 31. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Fatty Acid Metabolism (Adj. P: 0.008, Combined Score: 339.24) *(Total significant: 1)*
- Human_Phenotype_Ontology: Tetraparesis (HP:0002273) (Adj. P: 0.020, Combined Score: 2398.85); Heterotopia (HP:0002282) (Adj. P: 0.020, Combined Score: 1066.85); Poor eye contact (HP:0000817) (Adj. P: 0.020, Combined Score: 992.88); Abnormal social behavior (HP:0012433) (Adj. P: 0.020, Combined Score: 730.06); Impaired social interactions (HP:0000735) (Adj. P: 0.020, Combined Score: 730.06) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- OMIM_Disease: microcephaly (Adj. P: 0.010, Combined Score: 1362.86); hypertension (Adj. P: 0.010, Combined Score: 546.01) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 11 genes.
Average Silhouette Score: -0.018.
Highest expression is observed in: basal_ganglia__choroid plexus epithelial cell, hypothalamus__oligodendrocyte, amygdala__oligodendrocyte, thalamus__oligodendrocyte, basal_ganglia__oligodendrocyte.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Longevity (EFO:0004300) (FDR: 0.003) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of T-helper 17 Type Immune Response (GO:2000317) (Adj. P: 0.049, Combined Score: 2946.37); - Reg of Adaptive Imm Resp Based on Som Recomb of Imm Rcptrs Built Frm IgSF Domains (GO:0002823) (Adj. P: 0.049, Combined Score: 2284.21); Regulation of T-helper Cell Differentiation (GO:0045622) (Adj. P: 0.049, Combined Score: 2284.21); Regulation of Antigen Receptor-Mediated Signaling Pathway (GO:0050854) (Adj. P: 0.049, Combined Score: 1852.16); Regulation of miRNA Metabolic Process (GO:2000628) (Adj. P: 0.049, Combined Score: 1549.44) ... *(Total significant: 11. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: IL-2/STAT5 Signaling (Adj. P: 0.036, Combined Score: 117.82) *(Total significant: 1)*
- Human_Phenotype_Ontology: Reduced antithrombin III activity (HP:0001976) (Adj. P: 0.037, Combined Score: 1326.33); Deep venous thrombosis (HP:0002625) (Adj. P: 0.037, Combined Score: 1326.33); Personality changes (HP:0000751) (Adj. P: 0.039, Combined Score: 583.76); Acute myeloid leukemia (HP:0004808) (Adj. P: 0.039, Combined Score: 397.13); Neuronal loss in central nervous system (HP:0002529) (Adj. P: 0.039, Combined Score: 376.17) ... *(Total significant: 11. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 14 genes.
Average Silhouette Score: 0.219.
Highest expression is observed in: hippocampus__hippocampal dentate gyrus, hypothalamus__amygdala excitatory, hippocampus__hippocampal ca4, amygdala__oligodendrocyte precursor cell, midbrain__hippocampal dentate gyrus.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- TISSUES: Limbic system (BTO:0000928) (FDR: 0.027); Forebrain (BTO:0000478) (FDR: 0.045) *(Total significant: 2)*
- HPO: Cognitive function measurement (EFO:0008354) (FDR: 0.002); Self reported educational attainment (EFO:0004784) (FDR: 0.015) *(Total significant: 2)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Collateral Sprouting (GO:0048671) (Adj. P: 0.041, Combined Score: 2173.55); Positive Regulation of T-helper 2 Cell Differentiation (GO:0045630) (Adj. P: 0.041, Combined Score: 2173.55); Regulation of Immunoglobulin Mediated Immune Response (GO:0002889) (Adj. P: 0.041, Combined Score: 2173.55); Neurotransmitter Receptor Transport, Endosome to Plasma Membrane (GO:0099639) (Adj. P: 0.041, Combined Score: 2173.55); CD4-positive, Alpha-Beta T Cell Activation (GO:0035710) (Adj. P: 0.041, Combined Score: 1682.80) ... *(Total significant: 53. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Dehydroascorbic Acid Transmembrane Transporter Activity (GO:0033300) (Adj. P: 0.037, Combined Score: 1362.86); High Voltage-Gated Calcium Channel Activity (GO:0008331) (Adj. P: 0.037, Combined Score: 602.21); Ionotropic Glutamate Receptor Binding (GO:0035255) (Adj. P: 0.037, Combined Score: 547.14); Phosphatidylethanolamine Binding (GO:0008429) (Adj. P: 0.037, Combined Score: 547.14); Syntaxin-1 Binding (GO:0017075) (Adj. P: 0.037, Combined Score: 500.50) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Asymmetric, Glutamatergic, Excitatory Synapse (GO:0098985) (Adj. P: 0.028, Combined Score: 2173.55); Dendritic Spine Membrane (GO:0032591) (Adj. P: 0.028, Combined Score: 1362.86); Primary Lysosome (GO:0005766) (Adj. P: 0.032, Combined Score: 748.30); Specific Granule Lumen (GO:0035580) (Adj. P: 0.024, Combined Score: 400.48); Asymmetric Synapse (GO:0032279) (Adj. P: 0.028, Combined Score: 143.79) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Spermatogenesis (Adj. P: 0.012, Combined Score: 137.98) *(Total significant: 1)*
- Human_Phenotype_Ontology: Leiomyosarcoma (HP:0100243) (Adj. P: 0.034, Combined Score: 345.57); Uterine leiomyosarcoma (HP:0002891) (Adj. P: 0.034, Combined Score: 345.57); Transitional cell carcinoma of the bladder (HP:0006740) (Adj. P: 0.034, Combined Score: 305.71); Hereditary nonpolyposis colorectal carcinoma (HP:0006716) (Adj. P: 0.034, Combined Score: 288.72); Bladder carcinoma (HP:0002862) (Adj. P: 0.034, Combined Score: 273.33) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- OMIM_Disease: myocardial infarction (Adj. P: 0.022, Combined Score: 460.53); colorectal cancer (Adj. P: 0.028, Combined Score: 141.17) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 10 genes.
Average Silhouette Score: 0.073.
Highest expression is observed in: spinal_cord__committed oligodendrocyte precursor, hippocampus__committed oligodendrocyte precursor, cerebellum__committed oligodendrocyte precursor, midbrain__committed oligodendrocyte precursor, amygdala__oligodendrocyte precursor cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- NetworkNeighborAL: Mixed, incl. Domain of unknown function DUF4537, and CCDC92/74, N-terminal (CL:26850) (FDR: 0.038); Mixed, incl. Serine incorporator (Serinc), and Na,K-Atpase Interacting protein (CL:31379) (FDR: 0.038) *(Total significant: 2)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Cardiac Muscle Cell Differentiation (GO:2000726) (Adj. P: 0.039, Combined Score: 3326.77); Negative Regulation of Cardiocyte Differentiation (GO:1905208) (Adj. P: 0.039, Combined Score: 2580.41); Neuron Fate Specification (GO:0048665) (Adj. P: 0.039, Combined Score: 1751.86); Regulation of Cardiac Muscle Cell Differentiation (GO:2000725) (Adj. P: 0.039, Combined Score: 1500.17); Cell Differentiation in Spinal Cord (GO:0021515) (Adj. P: 0.039, Combined Score: 1500.17) ... *(Total significant: 21. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Potassium:Proton Antiporter Activity (GO:0015386) (Adj. P: 0.019, Combined Score: 1155.57); Sodium:Proton Antiporter Activity (GO:0015385) (Adj. P: 0.019, Combined Score: 932.06); Solute:Potassium Antiporter Activity (GO:0022821) (Adj. P: 0.019, Combined Score: 776.21); Histone Deacetylase Activity (GO:0004407) (Adj. P: 0.020, Combined Score: 538.34); Metal Cation:Proton Antiporter Activity (GO:0051139) (Adj. P: 0.020, Combined Score: 506.01) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 17 genes.
Average Silhouette Score: 0.110.
Highest expression is observed in: amygdala__oligodendrocyte, hypothalamus__oligodendrocyte, hypothalamus__leukocyte, amygdala__central nervous system macrophage, hypothalamus__central nervous system macrophage.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- SMART: Domain in SPla and the RYanodine Receptor. (SM00449) (FDR: 0.010); Associated with SPRY domains (SM00589) (FDR: 0.010) *(Total significant: 2)*
- PMID: (1997) A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID:9149941) (FDR: 0.007) *(Total significant: 1)*
- HPO: Wellbeing measurement (EFO:0007869) (FDR: 4.61e-08); Depressive symptom measurement (EFO:0007006) (FDR: 0.008) *(Total significant: 2)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- Reactome_2022: Butyrophilin (BTN) Family Interactions R-HSA-8851680 (Adj. P: 0.001, Combined Score: 2667.47); RAC2 GTPase Cycle R-HSA-9013404 (Adj. P: 0.023, Combined Score: 187.79); RAC3 GTPase Cycle R-HSA-9013423 (Adj. P: 0.023, Combined Score: 171.53); Adaptive Immune System R-HSA-1280218 (Adj. P: 0.023, Combined Score: 47.46) *(Total significant: 4)*
- OMIM_Disease: alzheimer disease (Adj. P: 0.044, Combined Score: 190.71) *(Total significant: 1)*
Top Genes (by silhouette):
This cluster contains 7 genes.
Average Silhouette Score: 0.037.
Highest expression is observed in: hypothalamus__endothelial cell, basal_ganglia__endothelial cell, cerebellum__endothelial cell, midbrain__endothelial cell, amygdala__endothelial cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- PMID: (2010) Identification of two novel chromosome regions associated with isolated growth hormone deficiency. (PMID:21284329) (FDR: 0.017) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of Peroxisome Proliferator Activated Receptor Signaling Pathway (GO:0035360) (Adj. P: 0.024, Combined Score: 5287.72); tRNA Aminoacylation for Mitochondrial Protein Translation (GO:0070127) (Adj. P: 0.024, Combined Score: 3338.15); Negative Regulation of Nitric Oxide Biosynthetic Process (GO:0045019) (Adj. P: 0.024, Combined Score: 2797.66); Negative Regulation of Nitric Oxide Metabolic Process (GO:1904406) (Adj. P: 0.024, Combined Score: 2797.66); NAD Biosynthesis via Nicotinamide Riboside Salvage Pathway (GO:0034356) (Adj. P: 0.024, Combined Score: 2398.85) ... *(Total significant: 55. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Galactosyltransferase Activity (GO:0008378) (Adj. P: 0.020, Combined Score: 2093.27); GABA Receptor Binding (GO:0050811) (Adj. P: 0.020, Combined Score: 2093.27); Intramolecular Oxidoreductase Activity, Transposing C=C Bonds (GO:0016863) (Adj. P: 0.020, Combined Score: 1497.03); UDP-galactosyltransferase Activity (GO:0035250) (Adj. P: 0.021, Combined Score: 818.24); Protein Kinase A Regulatory Subunit Binding (GO:0034237) (Adj. P: 0.021, Combined Score: 730.06) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Reactome_2022: Beta-oxidation Of Very Long Chain Fatty Acids R-HSA-390247 (Adj. P: 0.029, Combined Score: 1852.16); Eicosanoids R-HSA-211979 (Adj. P: 0.029, Combined Score: 1657.40); Synthesis Of Bile Acids And Bile Salts Via 24-Hydroxycholesterol R-HSA-193775 (Adj. P: 0.029, Combined Score: 1362.86); N-Glycan Antennae Elongation R-HSA-975577 (Adj. P: 0.029, Combined Score: 1249.08); Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) R-HSA-2162123 (Adj. P: 0.029, Combined Score: 1249.08) ... *(Total significant: 31. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Fatty Acid Metabolism (Adj. P: 0.008, Combined Score: 339.24) *(Total significant: 1)*
- Human_Phenotype_Ontology: Tetraparesis (HP:0002273) (Adj. P: 0.020, Combined Score: 2398.85); Heterotopia (HP:0002282) (Adj. P: 0.020, Combined Score: 1066.85); Poor eye contact (HP:0000817) (Adj. P: 0.020, Combined Score: 992.88); Abnormal social behavior (HP:0012433) (Adj. P: 0.020, Combined Score: 730.06); Impaired social interactions (HP:0000735) (Adj. P: 0.020, Combined Score: 730.06) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- OMIM_Disease: microcephaly (Adj. P: 0.010, Combined Score: 1362.86); hypertension (Adj. P: 0.010, Combined Score: 546.01) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 5 genes.
Average Silhouette Score: 0.042.
Highest expression is observed in: hypothalamus__oligodendrocyte, basal_ganglia__choroid plexus epithelial cell, amygdala__oligodendrocyte, thalamus__oligodendrocyte, cerebellum__oligodendrocyte.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of T-helper 17 Type Immune Response (GO:2000317) (Adj. P: 0.016, Combined Score: 8352.53); - Reg of Adaptive Imm Resp Based on Som Recomb of Imm Rcptrs Built Frm IgSF Domains (GO:0002823) (Adj. P: 0.016, Combined Score: 6499.56); Regulation of T-helper Cell Differentiation (GO:0045622) (Adj. P: 0.016, Combined Score: 6499.56); Regulation of Antigen Receptor-Mediated Signaling Pathway (GO:0050854) (Adj. P: 0.016, Combined Score: 5287.72); Regulation of miRNA Metabolic Process (GO:2000628) (Adj. P: 0.016, Combined Score: 4436.86) ... *(Total significant: 57. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: RNA Stem-Loop Binding (GO:0035613) (Adj. P: 0.035, Combined Score: 2638.91); Phosphatidylinositol Phospholipase C Activity (GO:0004435) (Adj. P: 0.035, Combined Score: 1111.12); Phospholipase C Activity (GO:0004629) (Adj. P: 0.035, Combined Score: 1006.18); miRNA Binding (GO:0035198) (Adj. P: 0.035, Combined Score: 842.66); Regulatory RNA Binding (GO:0061980) (Adj. P: 0.035, Combined Score: 538.86) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: UV Response Up (Adj. P: 0.049, Combined Score: 102.58); IL-2/STAT5 Signaling (Adj. P: 0.049, Combined Score: 75.50); KRAS Signaling Up (Adj. P: 0.049, Combined Score: 75.00); E2F Targets (Adj. P: 0.049, Combined Score: 75.00) *(Total significant: 4)*
Top Genes (by silhouette):
This cluster contains 6 genes.
Average Silhouette Score: 0.005.
Highest expression is observed in: amygdala__central nervous system macrophage, hypothalamus__upper-layer intratelencephalic, amygdala__astrocyte, basal_ganglia__choroid plexus epithelial cell, hypothalamus__fibroblast.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Molecular_Function_2025: G Protein-Coupled Photoreceptor Activity (GO:0008020) (Adj. P: 0.025, Combined Score: 2044.88) *(Total significant: 1)*
- GO_Cellular_Component_2025: Mitochondrial Ribosome (GO:0005761) (Adj. P: 0.028, Combined Score: 1012.63); Mitochondrial Matrix (GO:0005759) (Adj. P: 0.028, Combined Score: 124.26) *(Total significant: 2)*
- Reactome_2022: Intrinsic Pathway Of Fibrin Clot Formation R-HSA-140837 (Adj. P: 0.043, Combined Score: 1012.63); Common Pathway Of Fibrin Clot Formation R-HSA-140875 (Adj. P: 0.043, Combined Score: 955.53); Formation Of Fibrin Clot (Clotting Cascade) R-HSA-140877 (Adj. P: 0.048, Combined Score: 499.54); Mitochondrial Translation Elongation R-HSA-5389840 (Adj. P: 0.048, Combined Score: 182.67); Mitochondrial Translation Initiation R-HSA-5368286 (Adj. P: 0.048, Combined Score: 182.67) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Reduced antithrombin III activity (HP:0001976) (Adj. P: 0.016, Combined Score: 2955.69); Deep venous thrombosis (HP:0002625) (Adj. P: 0.016, Combined Score: 2955.69); Personality changes (HP:0000751) (Adj. P: 0.018, Combined Score: 1318.68); Acute myeloid leukemia (HP:0004808) (Adj. P: 0.018, Combined Score: 904.00); Neuronal loss in central nervous system (HP:0002529) (Adj. P: 0.018, Combined Score: 857.29) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 14 genes.
Average Silhouette Score: 0.182.
Highest expression is observed in: hippocampus__hippocampal dentate gyrus, hypothalamus__amygdala excitatory, hippocampus__hippocampal ca4, amygdala__oligodendrocyte precursor cell, midbrain__hippocampal dentate gyrus.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- TISSUES: Limbic system (BTO:0000928) (FDR: 0.027); Forebrain (BTO:0000478) (FDR: 0.045) *(Total significant: 2)*
- HPO: Cognitive function measurement (EFO:0008354) (FDR: 0.002); Self reported educational attainment (EFO:0004784) (FDR: 0.015) *(Total significant: 2)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Collateral Sprouting (GO:0048671) (Adj. P: 0.041, Combined Score: 2173.55); Positive Regulation of T-helper 2 Cell Differentiation (GO:0045630) (Adj. P: 0.041, Combined Score: 2173.55); Regulation of Immunoglobulin Mediated Immune Response (GO:0002889) (Adj. P: 0.041, Combined Score: 2173.55); Neurotransmitter Receptor Transport, Endosome to Plasma Membrane (GO:0099639) (Adj. P: 0.041, Combined Score: 2173.55); CD4-positive, Alpha-Beta T Cell Activation (GO:0035710) (Adj. P: 0.041, Combined Score: 1682.80) ... *(Total significant: 53. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Dehydroascorbic Acid Transmembrane Transporter Activity (GO:0033300) (Adj. P: 0.037, Combined Score: 1362.86); High Voltage-Gated Calcium Channel Activity (GO:0008331) (Adj. P: 0.037, Combined Score: 602.21); Ionotropic Glutamate Receptor Binding (GO:0035255) (Adj. P: 0.037, Combined Score: 547.14); Phosphatidylethanolamine Binding (GO:0008429) (Adj. P: 0.037, Combined Score: 547.14); Syntaxin-1 Binding (GO:0017075) (Adj. P: 0.037, Combined Score: 500.50) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Asymmetric, Glutamatergic, Excitatory Synapse (GO:0098985) (Adj. P: 0.028, Combined Score: 2173.55); Dendritic Spine Membrane (GO:0032591) (Adj. P: 0.028, Combined Score: 1362.86); Primary Lysosome (GO:0005766) (Adj. P: 0.032, Combined Score: 748.30); Specific Granule Lumen (GO:0035580) (Adj. P: 0.024, Combined Score: 400.48); Asymmetric Synapse (GO:0032279) (Adj. P: 0.028, Combined Score: 143.79) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Spermatogenesis (Adj. P: 0.012, Combined Score: 137.98) *(Total significant: 1)*
- Human_Phenotype_Ontology: Leiomyosarcoma (HP:0100243) (Adj. P: 0.034, Combined Score: 345.57); Uterine leiomyosarcoma (HP:0002891) (Adj. P: 0.034, Combined Score: 345.57); Transitional cell carcinoma of the bladder (HP:0006740) (Adj. P: 0.034, Combined Score: 305.71); Hereditary nonpolyposis colorectal carcinoma (HP:0006716) (Adj. P: 0.034, Combined Score: 288.72); Bladder carcinoma (HP:0002862) (Adj. P: 0.034, Combined Score: 273.33) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- OMIM_Disease: myocardial infarction (Adj. P: 0.022, Combined Score: 460.53); colorectal cancer (Adj. P: 0.028, Combined Score: 141.17) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 4 genes.
Average Silhouette Score: 0.265.
Highest expression is observed in: amygdala__ependymal cell, basal_ganglia__ependymal cell, hypothalamus__ependymal cell, hippocampus__ependymal cell, thalamus__ependymal cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- NetworkNeighborAL: Mixed, incl. Serine incorporator (Serinc), and Na,K-Atpase Interacting protein (CL:31379) (FDR: 0.006) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Cilium Movement Involved in Cell Motility (GO:0060294) (Adj. P: 0.018, Combined Score: 1935.63); Sodium Ion Import Across Plasma Membrane (GO:0098719) (Adj. P: 0.018, Combined Score: 1629.20); Cilium-Dependent Cell Motility (GO:0060285) (Adj. P: 0.018, Combined Score: 1337.30); Cilium Movement (GO:0003341) (Adj. P: 0.031, Combined Score: 469.28); Sodium Ion Transmembrane Transport (GO:0035725) (Adj. P: 0.032, Combined Score: 313.14) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Potassium:Proton Antiporter Activity (GO:0015386) (Adj. P: 0.005, Combined Score: 4077.19); Sodium:Proton Antiporter Activity (GO:0015385) (Adj. P: 0.005, Combined Score: 3304.67); Solute:Potassium Antiporter Activity (GO:0022821) (Adj. P: 0.005, Combined Score: 2764.28); Metal Cation:Proton Antiporter Activity (GO:0051139) (Adj. P: 0.005, Combined Score: 1822.54); Sodium Ion Transmembrane Transporter Activity (GO:0015081) (Adj. P: 0.008, Combined Score: 824.08) *(Total significant: 5)*
- GO_Cellular_Component_2025: Motile Cilium (GO:0031514) (Adj. P: 0.028, Combined Score: 322.45); 9+2 Motile Cilium (GO:0097729) (Adj. P: 0.028, Combined Score: 170.76) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 6 genes.
Average Silhouette Score: 0.029.
Highest expression is observed in: spinal_cord__committed oligodendrocyte precursor, hippocampus__committed oligodendrocyte precursor, cerebellum__committed oligodendrocyte precursor, midbrain__committed oligodendrocyte precursor, amygdala__oligodendrocyte precursor cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Cardiac Muscle Cell Differentiation (GO:2000726) (Adj. P: 0.016, Combined Score: 6499.56); Negative Regulation of Cardiocyte Differentiation (GO:1905208) (Adj. P: 0.016, Combined Score: 5053.71); Neuron Fate Specification (GO:0048665) (Adj. P: 0.016, Combined Score: 3445.29); Regulation of Cardiac Muscle Cell Differentiation (GO:2000725) (Adj. P: 0.016, Combined Score: 2955.69); Cell Differentiation in Spinal Cord (GO:0021515) (Adj. P: 0.016, Combined Score: 2955.69) ... *(Total significant: 31. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Histone Deacetylase Activity (GO:0004407) (Adj. P: 0.015, Combined Score: 1076.21); Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000987) (Adj. P: 5.28e-04, Combined Score: 339.42); RNA Polymerase II Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000978) (Adj. P: 5.28e-04, Combined Score: 330.37); RNA Polymerase II Transcription Regulatory Region Sequence-Specific DNA Binding (GO:0000977) (Adj. P: 6.56e-04, Combined Score: 259.89); Histone Deacetylase Binding (GO:0042826) (Adj. P: 0.049, Combined Score: 141.43) ... *(Total significant: 6. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 6 genes.
Average Silhouette Score: 0.195.
Highest expression is observed in: hypothalamus__oligodendrocyte, amygdala__oligodendrocyte, basal_ganglia__oligodendrocyte, hippocampus__oligodendrocyte, cerebral_cortex__oligodendrocyte.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Wellbeing measurement (EFO:0007869) (FDR: 0.002) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Interleukin-1-Mediated Signaling Pathway (GO:2000659) (Adj. P: 0.023, Combined Score: 5053.71); Cellular Response to Iron Ion (GO:0071281) (Adj. P: 0.023, Combined Score: 5053.71); Negative Regulation of CD8-positive, Alpha-Beta T Cell Activation (GO:2001186) (Adj. P: 0.023, Combined Score: 4108.59); Negative Regulation of T Cell Cytokine Production (GO:0002725) (Adj. P: 0.023, Combined Score: 3445.29); Positive Regulation of Peptide Secretion (GO:0002793) (Adj. P: 0.023, Combined Score: 3445.29) ... *(Total significant: 65. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Transferrin Receptor Binding (GO:1990459) (Adj. P: 0.042, Combined Score: 2580.41) *(Total significant: 1)*
- GO_Cellular_Component_2025: MHC Class I Protein Complex (GO:0042612) (Adj. P: 0.027, Combined Score: 6499.56); HFE-transferrin Receptor Complex (GO:1990712) (Adj. P: 0.027, Combined Score: 4108.59); MHC Protein Complex (GO:0042611) (Adj. P: 0.050, Combined Score: 1076.21); Lumenal Side of Endoplasmic Reticulum Membrane (GO:0098553) (Adj. P: 0.050, Combined Score: 598.87); Phagocytic Vesicle Membrane (GO:0030670) (Adj. P: 0.050, Combined Score: 360.44) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Testicular atrophy (HP:0000029) (Adj. P: 0.019, Combined Score: 3445.29); Arthropathy (HP:0003040) (Adj. P: 0.019, Combined Score: 2580.41); Azoospermia (HP:0000027) (Adj. P: 0.019, Combined Score: 1847.77); Abnormal glucose tolerance (HP:0001952) (Adj. P: 0.019, Combined Score: 1682.80); Cerebral palsy (HP:0100021) (Adj. P: 0.019, Combined Score: 1682.80) ... *(Total significant: 27. See enrichr_terms.csv for full list.)*
- OMIM_Disease: alzheimer disease (Adj. P: 0.016, Combined Score: 775.88); diabetes (Adj. P: 0.022, Combined Score: 204.77) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 5 genes.
Average Silhouette Score: 0.007.
Highest expression is observed in: amygdala__oligodendrocyte precursor cell, hippocampus__oligodendrocyte precursor cell, hypothalamus__oligodendrocyte precursor cell, basal_ganglia__oligodendrocyte precursor cell, cerebral_cortex__oligodendrocyte precursor cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Golgi to Endosome Transport (GO:0006895) (Adj. P: 0.035, Combined Score: 1993.61); Positive Regulation of Stress-Activated MAPK Cascade (GO:0032874) (Adj. P: 0.035, Combined Score: 1839.15); Positive Regulation of Stress-Activated Protein Kinase Signaling Cascade (GO:0070304) (Adj. P: 0.035, Combined Score: 1839.15); Response to Interferon-Alpha (GO:0035455) (Adj. P: 0.035, Combined Score: 1484.80); Positive Regulation of JUN Kinase Activity (GO:0043507) (Adj. P: 0.035, Combined Score: 1111.12) ... *(Total significant: 22. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Ubiquitin-Like Ligase-Substrate Adaptor Activity (GO:1990756) (Adj. P: 0.003, Combined Score: 912.05); Kinase Inhibitor Activity (GO:0019210) (Adj. P: 0.043, Combined Score: 628.43); Protein Kinase Inhibitor Activity (GO:0004860) (Adj. P: 0.043, Combined Score: 370.72) *(Total significant: 3)*
- GO_Cellular_Component_2025: cullin-RING Ubiquitin Ligase Complex (GO:0031461) (Adj. P: 0.011, Combined Score: 410.30); SCF Ubiquitin Ligase Complex (GO:0019005) (Adj. P: 0.040, Combined Score: 370.72); Cul3-RING Ubiquitin Ligase Complex (GO:0031463) (Adj. P: 0.040, Combined Score: 370.72); Mitochondrial Intermembrane Space (GO:0005758) (Adj. P: 0.040, Combined Score: 287.37) *(Total significant: 4)*
- Reactome_2022: Butyrophilin (BTN) Family Interactions R-HSA-8851680 (Adj. P: 0.010, Combined Score: 2638.91); Neddylation R-HSA-8951664 (Adj. P: 0.010, Combined Score: 369.75); Adaptive Immune System R-HSA-1280218 (Adj. P: 0.007, Combined Score: 303.85); Antigen Processing: Ubiquitination And Proteasome Degradation R-HSA-983168 (Adj. P: 0.010, Combined Score: 261.87); RAC2 GTPase Cycle R-HSA-9013404 (Adj. P: 0.043, Combined Score: 222.05) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Abnormality of alanine metabolism (HP:0010916) (Adj. P: 0.019, Combined Score: 4436.86); Abnormality of pyruvate family amino acid metabolism (HP:0010915) (Adj. P: 0.019, Combined Score: 4436.86); Hyperalaninemia (HP:0003348) (Adj. P: 0.019, Combined Score: 4436.86); Renal tubular acidosis (HP:0001947) (Adj. P: 0.025, Combined Score: 1588.07); Abnormality of serum amino acid levels (HP:0003112) (Adj. P: 0.025, Combined Score: 917.89) ... *(Total significant: 26. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 6 genes.
Average Silhouette Score: 0.039.
Highest expression is observed in: hypothalamus__leukocyte, basal_ganglia__endothelial cell, cerebellum__leukocyte, midbrain__leukocyte, amygdala__leukocyte.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Process: Regulation of viral genome replication (GO:0045069) (FDR: 0.028) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Intracellular mRNA Localization (GO:0008298) (Adj. P: 0.019, Combined Score: 6499.56); Regulatory ncRNA-mediated Heterochromatin Formation (GO:0031048) (Adj. P: 0.019, Combined Score: 4108.59); Anterograde Dendritic Transport (GO:0098937) (Adj. P: 0.019, Combined Score: 4108.59); Modulation by Symbiont of Entry Into Host (GO:0052372) (Adj. P: 0.019, Combined Score: 2580.41); Positive Regulation by Symbiont of Entry Into Host (GO:0075294) (Adj. P: 0.019, Combined Score: 1847.77) ... *(Total significant: 31. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Cytoplasmic Stress Granule (GO:0010494) (Adj. P: 0.003, Combined Score: 1002.91) *(Total significant: 1)*
- Reactome_2022: Butyrophilin (BTN) Family Interactions R-HSA-8851680 (Adj. P: 0.022, Combined Score: 2044.88) *(Total significant: 1)*
Top Genes (by silhouette):
This cluster contains 4 genes.
Average Silhouette Score: 0.066.
Highest expression is observed in: hypothalamus__endothelial cell, basal_ganglia__endothelial cell, midbrain__endothelial cell, cerebellum__endothelial cell, amygdala__endothelial cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: tRNA Aminoacylation for Mitochondrial Protein Translation (GO:0070127) (Adj. P: 0.022, Combined Score: 7298.30); Central Nervous System Neuron Axonogenesis (GO:0021955) (Adj. P: 0.022, Combined Score: 5264.00); Central Nervous System Myelination (GO:0022010) (Adj. P: 0.022, Combined Score: 4077.19); Ganglioside Biosynthetic Process (GO:0001574) (Adj. P: 0.022, Combined Score: 2764.28); Central Nervous System Neuron Development (GO:0021954) (Adj. P: 0.022, Combined Score: 2764.28) ... *(Total significant: 32. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: GABA Receptor Binding (GO:0050811) (Adj. P: 0.012, Combined Score: 4600.93); Galactosyltransferase Activity (GO:0008378) (Adj. P: 0.012, Combined Score: 4600.93); UDP-galactosyltransferase Activity (GO:0035250) (Adj. P: 0.014, Combined Score: 1822.54); Protein Kinase A Regulatory Subunit Binding (GO:0034237) (Adj. P: 0.014, Combined Score: 1629.20); aminoacyl-tRNA Ligase Activity (GO:0004812) (Adj. P: 0.018, Combined Score: 877.91) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Golgi Membrane (GO:0000139) (Adj. P: 0.039, Combined Score: 235.51) *(Total significant: 1)*
- Reactome_2022: N-Glycan Antennae Elongation R-HSA-975577 (Adj. P: 0.020, Combined Score: 2764.28); Mitochondrial tRNA Aminoacylation R-HSA-379726 (Adj. P: 0.020, Combined Score: 1822.54); N-glycan Antennae Elongation In medial/trans-Golgi R-HSA-975576 (Adj. P: 0.020, Combined Score: 1400.90); Keratan Sulfate Biosynthesis R-HSA-2022854 (Adj. P: 0.020, Combined Score: 1278.76); Keratan Sulfate/Keratin Metabolism R-HSA-1638074 (Adj. P: 0.020, Combined Score: 1044.60) ... *(Total significant: 14. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Protein Secretion (Adj. P: 0.038, Combined Score: 276.52); TNF-alpha Signaling via NF-kB (Adj. P: 0.039, Combined Score: 107.24) *(Total significant: 2)*
- Human_Phenotype_Ontology: Tetraparesis (HP:0002273) (Adj. P: 0.012, Combined Score: 5264.00); Heterotopia (HP:0002282) (Adj. P: 0.012, Combined Score: 2366.46); Poor eye contact (HP:0000817) (Adj. P: 0.012, Combined Score: 2204.79); Abnormal social behavior (HP:0012433) (Adj. P: 0.012, Combined Score: 1629.20); Impaired social interactions (HP:0000735) (Adj. P: 0.012, Combined Score: 1629.20) ... *(Total significant: 15. See enrichr_terms.csv for full list.)*
- OMIM_Disease: microcephaly (Adj. P: 0.003, Combined Score: 3012.37) *(Total significant: 1)*
Top Genes (by silhouette):
This cluster contains 3 genes.
Average Silhouette Score: -0.007.
Highest expression is observed in: cerebellum__astrocyte, hypothalamus__vascular associated smooth muscle cell, pons__astrocyte, pons__fibroblast, hypothalamus__endothelial cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of Peroxisome Proliferator Activated Receptor Signaling Pathway (GO:0035360) (Adj. P: 0.008, Combined Score: 17982.86); Negative Regulation of Nitric Oxide Biosynthetic Process (GO:0045019) (Adj. P: 0.008, Combined Score: 9603.49); Negative Regulation of Nitric Oxide Metabolic Process (GO:1904406) (Adj. P: 0.008, Combined Score: 9603.49); NAD Biosynthesis via Nicotinamide Riboside Salvage Pathway (GO:0034356) (Adj. P: 0.008, Combined Score: 8255.55); NAD Biosynthetic Process via the Salvage Pathway (GO:0034355) (Adj. P: 0.008, Combined Score: 7220.95) ... *(Total significant: 42. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Intramolecular Oxidoreductase Activity, Transposing C=C Bonds (GO:0016863) (Adj. P: 0.002, Combined Score: 5196.55) *(Total significant: 1)*
- GO_Cellular_Component_2025: Microbody Lumen (GO:0031907) (Adj. P: 0.025, Combined Score: 996.45); Peroxisomal Matrix (GO:0005782) (Adj. P: 0.025, Combined Score: 996.45); Caveola (GO:0005901) (Adj. P: 0.025, Combined Score: 764.89); Plasma Membrane Raft (GO:0044853) (Adj. P: 0.025, Combined Score: 533.11); Peroxisome (GO:0005777) (Adj. P: 0.032, Combined Score: 292.26) *(Total significant: 5)*
- Reactome_2022: Beta-oxidation Of Very Long Chain Fatty Acids R-HSA-390247 (Adj. P: 0.009, Combined Score: 6403.33); Eicosanoids R-HSA-211979 (Adj. P: 0.009, Combined Score: 5741.92); Synthesis Of Bile Acids And Bile Salts Via 24-Hydroxycholesterol R-HSA-193775 (Adj. P: 0.009, Combined Score: 4739.66); Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) R-HSA-2162123 (Adj. P: 0.009, Combined Score: 4351.69); Synthesis Of Bile Acids And Bile Salts Via 27-Hydroxycholesterol R-HSA-193807 (Adj. P: 0.009, Combined Score: 4351.69) ... *(Total significant: 24. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Fatty Acid Metabolism (Adj. P: 7.40e-04, Combined Score: 2186.25); Reactive Oxygen Species Pathway (Adj. P: 0.015, Combined Score: 1021.44); Pperoxisome (Adj. P: 0.021, Combined Score: 402.29); Myogenesis (Adj. P: 0.030, Combined Score: 174.93) *(Total significant: 4)*
- Human_Phenotype_Ontology: Multifactorial inheritance (HP:0001426) (Adj. P: 0.004, Combined Score: 2024.38) *(Total significant: 1)*
- OMIM_Disease: hypertension (Adj. P: 0.004, Combined Score: 1939.49) *(Total significant: 1)*
Top Genes (by silhouette):
This cluster contains 2 genes.
Average Silhouette Score: 0.061.
Highest expression is observed in: hypothalamus__oligodendrocyte, amygdala__oligodendrocyte, thalamus__oligodendrocyte, cerebellum__oligodendrocyte, basal_ganglia__oligodendrocyte.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Top Genes (by silhouette):
This cluster contains 3 genes.
Average Silhouette Score: 0.054.
Highest expression is observed in: basal_ganglia__choroid plexus epithelial cell, hypothalamus__upper rhombic lip, hypothalamus__leukocyte, medulla_oblongata__choroid plexus epithelial cell, pons__choroid plexus epithelial cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Longevity (EFO:0004300) (FDR: 0.031) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of T-helper 17 Type Immune Response (GO:2000317) (Adj. P: 0.008, Combined Score: 17982.86); - Reg of Adaptive Imm Resp Based on Som Recomb of Imm Rcptrs Built Frm IgSF Domains (GO:0002823) (Adj. P: 0.008, Combined Score: 14021.17); Regulation of T-helper Cell Differentiation (GO:0045622) (Adj. P: 0.008, Combined Score: 14021.17); Regulation of Antigen Receptor-Mediated Signaling Pathway (GO:0050854) (Adj. P: 0.008, Combined Score: 11427.00); Regulation of miRNA Metabolic Process (GO:2000628) (Adj. P: 0.008, Combined Score: 9603.49) ... *(Total significant: 48. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: RNA Stem-Loop Binding (GO:0035613) (Adj. P: 0.027, Combined Score: 5741.92); miRNA Binding (GO:0035198) (Adj. P: 0.032, Combined Score: 1860.86); Regulatory RNA Binding (GO:0061980) (Adj. P: 0.032, Combined Score: 1198.68); Double-Stranded RNA Binding (GO:0003725) (Adj. P: 0.040, Combined Score: 647.02); mRNA 3'-UTR Binding (GO:0003730) (Adj. P: 0.047, Combined Score: 397.49) *(Total significant: 5)*
- GO_Cellular_Component_2025: P-body (GO:0000932) (Adj. P: 0.031, Combined Score: 533.11); Cytoplasmic Stress Granule (GO:0010494) (Adj. P: 0.031, Combined Score: 525.23) *(Total significant: 2)*
- MSigDB_Hallmark_2020: IL-2/STAT5 Signaling (Adj. P: 0.030, Combined Score: 176.07); KRAS Signaling Up (Adj. P: 0.030, Combined Score: 174.93); E2F Targets (Adj. P: 0.030, Combined Score: 174.93) *(Total significant: 3)*
Top Genes (by silhouette):
This cluster contains 3 genes.
Average Silhouette Score: 0.121.
Highest expression is observed in: amygdala__central nervous system macrophage, hypothalamus__upper-layer intratelencephalic, basal_ganglia__choroid plexus epithelial cell, amygdala__astrocyte, hypothalamus__fibroblast.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Cyclin-Dependent Protein Serine/Threonine Kinase Activity (GO:0000079) (Adj. P: 0.027, Combined Score: 1103.68); Negative Regulation of Protein Serine/Threonine Kinase Activity (GO:0071901) (Adj. P: 0.027, Combined Score: 1103.68); RNA Modification (GO:0009451) (Adj. P: 0.027, Combined Score: 886.40); RNA Metabolic Process (GO:0016070) (Adj. P: 0.027, Combined Score: 749.95); tRNA Modification (GO:0006400) (Adj. P: 0.027, Combined Score: 647.02) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Spermatogenesis (Adj. P: 0.020, Combined Score: 289.52) *(Total significant: 1)*
- Human_Phenotype_Ontology: Personality changes (HP:0000751) (Adj. P: 0.012, Combined Score: 3729.25); Acute myeloid leukemia (HP:0004808) (Adj. P: 0.012, Combined Score: 2574.28); Neuronal loss in central nervous system (HP:0002529) (Adj. P: 0.012, Combined Score: 2443.77); Depression (HP:0000716) (Adj. P: 0.012, Combined Score: 1541.63); Bradykinesia (HP:0002067) (Adj. P: 0.012, Combined Score: 1440.46) ... *(Total significant: 11. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 2 genes.
Average Silhouette Score: -0.000.
Highest expression is observed in: hypothalamus__endothelial cell, medulla_oblongata__endothelial cell, cerebral_cortex__upper rhombic lip, hippocampus__endothelial cell, basal_ganglia__endothelial cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Top Genes (by silhouette):
This cluster contains 1 genes.
Average Silhouette Score: 0.000.
Highest expression is observed in: hippocampus__medium spiny neuron, amygdala__amygdala excitatory, midbrain__bergmann glia, midbrain__deep-layer corticothalamic and 6b, midbrain__committed oligodendrocyte precursor.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Top Genes (by silhouette):
This cluster contains 3 genes.
Average Silhouette Score: 0.061.
Highest expression is observed in: hypothalamus__upper rhombic lip, midbrain__upper rhombic lip, thalamus__upper rhombic lip, spinal_cord__upper rhombic lip, basal_ganglia__upper rhombic lip.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- TISSUES: Cerebellum (BTO:0000232) (FDR: 0.045) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Synaptic Vesicle Docking (GO:0016081) (Adj. P: 0.013, Combined Score: 8255.55); Synaptic Transmission, Glutamatergic (GO:0035249) (Adj. P: 0.019, Combined Score: 2216.11); Synaptic Vesicle Exocytosis (GO:0016079) (Adj. P: 0.021, Combined Score: 1198.68); Negative Regulation of MAPK Cascade (GO:0043409) (Adj. P: 0.044, Combined Score: 312.81); Brain Development (GO:0007420) (Adj. P: 0.044, Combined Score: 215.73) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Phosphatidylethanolamine Binding (GO:0008429) (Adj. P: 0.007, Combined Score: 4739.66); Syntaxin-1 Binding (GO:0017075) (Adj. P: 0.007, Combined Score: 4351.69); Hydro-Lyase Activity (GO:0016836) (Adj. P: 0.010, Combined Score: 1103.68); Syntaxin Binding (GO:0019905) (Adj. P: 0.010, Combined Score: 1103.68) *(Total significant: 4)*
- GO_Cellular_Component_2025: Neuromuscular Junction (GO:0031594) (Adj. P: 0.017, Combined Score: 1394.27); Exocytic Vesicle Membrane (GO:0099501) (Adj. P: 0.017, Combined Score: 695.09); Synaptic Vesicle Membrane (GO:0030672) (Adj. P: 0.017, Combined Score: 682.49) *(Total significant: 3)*
- Reactome_2022: Signaling By High-Kinase Activity BRAF Mutants R-HSA-6802948 (Adj. P: 0.018, Combined Score: 1656.47); MAP2K And MAPK Activation R-HSA-5674135 (Adj. P: 0.018, Combined Score: 1440.46); Paradoxical Activation Of RAF Signaling By Kinase Inactive BRAF R-HSA-6802955 (Adj. P: 0.018, Combined Score: 1270.59); Negative Regulation Of MAPK Pathway R-HSA-5675221 (Adj. P: 0.018, Combined Score: 1270.59); Signaling By BRAF And RAF1 Fusions R-HSA-6802952 (Adj. P: 0.022, Combined Score: 764.89) ... *(Total significant: 6. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Spermatogenesis (Adj. P: 0.020, Combined Score: 289.52) *(Total significant: 1)*
Top Genes (by silhouette):
This cluster contains 11 genes.
Average Silhouette Score: 0.146.
Highest expression is observed in: hippocampus__hippocampal ca4, hypothalamus__amygdala excitatory, thalamus__medium spiny neuron, amygdala__miscellaneous, hypothalamus__miscellaneous.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- HPO: Self reported educational attainment (EFO:0004784) (FDR: 0.003); Cognitive function measurement (EFO:0008354) (FDR: 0.003); Depressive symptom measurement (EFO:0007006) (FDR: 0.018) *(Total significant: 3)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Collateral Sprouting (GO:0048671) (Adj. P: 0.034, Combined Score: 2946.37); Positive Regulation of T-helper 2 Cell Differentiation (GO:0045630) (Adj. P: 0.034, Combined Score: 2946.37); Regulation of Immunoglobulin Mediated Immune Response (GO:0002889) (Adj. P: 0.034, Combined Score: 2946.37); Neurotransmitter Receptor Transport, Endosome to Plasma Membrane (GO:0099639) (Adj. P: 0.034, Combined Score: 2946.37); CD4-positive, Alpha-Beta T Cell Activation (GO:0035710) (Adj. P: 0.034, Combined Score: 2284.21) ... *(Total significant: 71. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Dehydroascorbic Acid Transmembrane Transporter Activity (GO:0033300) (Adj. P: 0.031, Combined Score: 1852.16); High Voltage-Gated Calcium Channel Activity (GO:0008331) (Adj. P: 0.031, Combined Score: 822.99); Ionotropic Glutamate Receptor Binding (GO:0035255) (Adj. P: 0.031, Combined Score: 748.30); Hexose Transmembrane Transporter Activity (GO:0015149) (Adj. P: 0.031, Combined Score: 630.75); Glutamate Receptor Binding (GO:0035254) (Adj. P: 0.031, Combined Score: 445.92) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Asymmetric, Glutamatergic, Excitatory Synapse (GO:0098985) (Adj. P: 0.017, Combined Score: 2946.37); Dendritic Spine Membrane (GO:0032591) (Adj. P: 0.017, Combined Score: 1852.16); Primary Lysosome (GO:0005766) (Adj. P: 0.022, Combined Score: 1020.97); Specific Granule Lumen (GO:0035580) (Adj. P: 0.013, Combined Score: 571.41); AMPA Glutamate Receptor Complex (GO:0032281) (Adj. P: 0.034, Combined Score: 420.26) ... *(Total significant: 17. See enrichr_terms.csv for full list.)*
- Reactome_2022: Netrin Mediated Repulsion Signals R-HSA-418886 (Adj. P: 0.041, Combined Score: 1549.44); Regulation Of Commissural Axon Pathfinding By SLIT And ROBO R-HSA-428542 (Adj. P: 0.041, Combined Score: 1326.33); Role Of Second Messengers In Netrin-1 Signaling R-HSA-418890 (Adj. P: 0.041, Combined Score: 1155.57); Caspase Activation Via Dependence Receptors In Absence Of Ligand R-HSA-418889 (Adj. P: 0.041, Combined Score: 1155.57); DSCAM Interactions R-HSA-376172 (Adj. P: 0.041, Combined Score: 1020.97) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Leiomyosarcoma (HP:0100243) (Adj. P: 0.027, Combined Score: 474.51); Uterine leiomyosarcoma (HP:0002891) (Adj. P: 0.027, Combined Score: 474.51); Transitional cell carcinoma of the bladder (HP:0006740) (Adj. P: 0.027, Combined Score: 420.26); Hereditary nonpolyposis colorectal carcinoma (HP:0006716) (Adj. P: 0.027, Combined Score: 397.13); Bladder carcinoma (HP:0002862) (Adj. P: 0.027, Combined Score: 376.17) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
- OMIM_Disease: myocardial infarction (Adj. P: 0.018, Combined Score: 630.75); colorectal cancer (Adj. P: 0.022, Combined Score: 195.74) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 4 genes.
Average Silhouette Score: 0.249.
Highest expression is observed in: amygdala__ependymal cell, basal_ganglia__ependymal cell, hypothalamus__ependymal cell, hippocampus__ependymal cell, thalamus__ependymal cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- NetworkNeighborAL: Mixed, incl. Serine incorporator (Serinc), and Na,K-Atpase Interacting protein (CL:31379) (FDR: 0.006) *(Total significant: 1)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Cilium Movement Involved in Cell Motility (GO:0060294) (Adj. P: 0.018, Combined Score: 1935.63); Sodium Ion Import Across Plasma Membrane (GO:0098719) (Adj. P: 0.018, Combined Score: 1629.20); Cilium-Dependent Cell Motility (GO:0060285) (Adj. P: 0.018, Combined Score: 1337.30); Cilium Movement (GO:0003341) (Adj. P: 0.031, Combined Score: 469.28); Sodium Ion Transmembrane Transport (GO:0035725) (Adj. P: 0.032, Combined Score: 313.14) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Potassium:Proton Antiporter Activity (GO:0015386) (Adj. P: 0.005, Combined Score: 4077.19); Sodium:Proton Antiporter Activity (GO:0015385) (Adj. P: 0.005, Combined Score: 3304.67); Solute:Potassium Antiporter Activity (GO:0022821) (Adj. P: 0.005, Combined Score: 2764.28); Metal Cation:Proton Antiporter Activity (GO:0051139) (Adj. P: 0.005, Combined Score: 1822.54); Sodium Ion Transmembrane Transporter Activity (GO:0015081) (Adj. P: 0.008, Combined Score: 824.08) *(Total significant: 5)*
- GO_Cellular_Component_2025: Motile Cilium (GO:0031514) (Adj. P: 0.028, Combined Score: 322.45); 9+2 Motile Cilium (GO:0097729) (Adj. P: 0.028, Combined Score: 170.76) *(Total significant: 2)*
Top Genes (by silhouette):
This cluster contains 4 genes.
Average Silhouette Score: 0.067.
Highest expression is observed in: spinal_cord__committed oligodendrocyte precursor, hippocampus__committed oligodendrocyte precursor, cerebellum__committed oligodendrocyte precursor, midbrain__committed oligodendrocyte precursor, amygdala__oligodendrocyte precursor cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Cardiac Muscle Cell Differentiation (GO:2000726) (Adj. P: 0.013, Combined Score: 11508.86); Negative Regulation of Cardiocyte Differentiation (GO:1905208) (Adj. P: 0.013, Combined Score: 8963.74); Neuron Fate Specification (GO:0048665) (Adj. P: 0.013, Combined Score: 6128.34); Regulation of Cardiac Muscle Cell Differentiation (GO:2000725) (Adj. P: 0.013, Combined Score: 5264.00); Cell Differentiation in Spinal Cord (GO:0021515) (Adj. P: 0.013, Combined Score: 5264.00) ... *(Total significant: 41. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Histone Deacetylase Activity (GO:0004407) (Adj. P: 0.035, Combined Score: 1935.63); Histone Deacetylase Binding (GO:0042826) (Adj. P: 0.035, Combined Score: 262.58); Sequence-Specific Double-Stranded DNA Binding (GO:1990837) (Adj. P: 0.035, Combined Score: 135.50); Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000987) (Adj. P: 0.035, Combined Score: 77.13); RNA Polymerase II Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000978) (Adj. P: 0.035, Combined Score: 75.03) ... *(Total significant: 6. See enrichr_terms.csv for full list.)*
Top Genes (by silhouette):
This cluster contains 2 genes.
Average Silhouette Score: -0.005.
Highest expression is observed in: amygdala__vascular associated smooth muscle cell, midbrain__ependymal cell, amygdala__fibroblast, spinal_cord__fibroblast, hippocampus__ependymal cell.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*
Top Genes (by silhouette):